Tuesday , February 27 2024

UCT Vacancies Cleaner – Medicinal Chemistry Investigator

Website University of Cape Town

Job Description:

The Drug Discovery and Development Centre (H3D http://www.h3d.uct.ac.za/ ) is an interdisciplinary, soft-funded research unit at the University of Cape Town. H3D staff and laboratories are situated across three sites on the UCT campus. H3D is seeking to appoint an Investigator on a 5-year contract for the the newly launched J&J Satellite Center for Global Health Discovery at H3D. The focus area for the centre is Antimicrobial Resistance, aiming to develop first in class MDR Gram-Negative therapeutics (read more here https://www.jnj.com/global-public-health/discovery-centers).
This position will be predominantly laboratory-based with the main purpose in taking a leading role in the synthesis of novel compounds to optimize drug-like properties on anti-bacterial drug discovery projects.

Job Responsibilities:

  • Participate and present work in project meetings and write research reports
  • Use structure-activity relationships and other medicinal chemistry practices to aid optimization of “hit to lead” and lead to preclinical candidate
  • Comply with standard operating procedures for laboratory safety, use of instruments and data management.
  • Independently synthesize compounds within a team setting with the goal to identify pre-clinical drug candidates.

Job Requirements:

  • Masters in appropriate discipline with 5 or more years industrial or academic experience in drug discovery or synthetic organic chemistry
  • A track record of publications in medicinal chemistry and/or organic chemistry journals with major contributions to compound synthesis
  • Up to date on laboratory technologies and strong bench experience in synthetic organic chemistry and characterisation of organic compounds
  • Proficiency in the use of all equipment in a modern chemistry laboratory including parallel synthesis, automated purifications techniques
  • PhD in an appropriate discipline with 2 or more years industrial or academic experience in drug discovery or synthetic organic chemistry OR;
  • Comfortable working in a matrix-based organizational structure
  • Experience in a drug discovery team either in a university setting or at a pharmaceutical/biotech company
  • Demonstrated ability to use structure-activity relationships and other medicinal chemistry practices to aid optimization of “hit to lead” and lead to preclinical candidate

Job Details:

Company: University of Cape Town

Vacancy Type: Full Time

Job Location: Cape Town, Western Cape, SA

Application Deadline: N/A

Apply Here